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KMID : 0380620180500030349
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Korean Journal of Food Science and Technology
2018 Volume.50 No. 3 p.349 ~ p.355
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Angiogenic effects of wood-cultivated ginseng extract and ginsenoside Rg5 in human umbilical vein endothelial cells
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Kim Na-Eun
Lee Mi-Ok
Jang Mi-Hee
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Abstract
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Ginsenoside Rg5, one of the protopanaxadiol ginsenosides of wood-cultivated ginseng, has been implicated in various diseases, such as diabetes, cancer, and hypertension; however, its angiogenic activity and molecular mechanisms have not yet been elucidated. Here, we found that wood-cultivated ginseng extract and ginsenoside Rg5 increase in vitro proliferation, migration, and tube-like structure formation, which are typical phenomena associated with angiogenesis, in cultured human umbilical vein endothelial cells (HUVECs). Moreover, Ginsenoside Rg5 stimulated the phosphorylation of Akt, endothelial nitric oxide (NO) synthase (eNOS), and extracellular-regulated kinase (ERK)1/2, which are well-known signal mediators of the angiogenic pathway. Furthermore, Ginsenoside Rg5 did not accelerate the activation of ICAM-1 and VCAM-1 which are inflammatory response mediators. These results suggest that wood-cultivated ginseng extract and ginsenoside Rg5 stimulated in vitro angiogenesis by activating the Akt/eNOS- and ERK1/2-dependent signal pathways without inducing vascular inflammation.
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KEYWORD
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angiogenesis, wood-cultivated ginseng ginsenoside Rg5, vascular endothelial growth factor, signal cascade
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